Nanopore technology for molecular diagnostics of the future (nanodiag BW)

The future cluster nanodiag BW, an association of regional, multidisciplinary actors funded within the framework of the future cluster initiative Clusters4Future, has set itself the goal of improving the molecular diagnostics of epigenetic factors, especially post-translational modifications of proteins. This will be achieved by applying nanopore technology and its transfer into application as routine molecular diagnostics. By using nanopores, molecular scale channels, in biosensors, post-translational modifications can be detected easily, faster and more reliably. The detection is based on the measurement of diminutive ionic currents in the pore, which vary depending on the nature of the molecule. The use of this technology also enables the discrimination of isomers of the same mass (molecules that differ only in the spatial arrangement of their atoms), which is a significant improvement compared to previous diagnostics. Thus, the development of miniaturized analytical devices and methods will improve the prevention, treatment and aftercare of common and serious diseases in the long term.

As an innovation partner, Steinbeis Europa Zentrum coordinates the continuation of the joint cluster and R&D strategy and supports the project's communication and dissemination activities as well as the exploitation of research results. Measures include analyses of the markets, patent landscape and value network. Thus ,this serves in particular to maximize the cluster output and accelerate the transfer of developments into spin-offs, disruptive services and products.

Further information:

• Project name (akronym): nanodiag BW
• Funding: BMBF, Ministerium für Wissenschaft, Forschung und Kunst,  Ministerium für Wirtschaft, Arbeit und Tourismus Baden-Württemberg
• Funding budget: 45 MEUR
• Participating cities: Freiburg/Stuttgart/Ulm
• Project duration: 04/2023 – 03/2026 (03/2032)